pleural effusion

Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

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Study Counts

Type	Study_count
Total_Studies	152
interventional	110
Observational	38
Registry	4

Studies over Time by Start Date

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Interventional Trials

Intervention Type

intervention_type	Study_Count
Drug	25
Procedure	23
Device	22
Other	10
Biological	5
Drug|Other	3
Drug|placebo	3
Biological|Drug	2
Device|Procedure	2
Diagnostic Test	2
Drug|Procedure	2
Other|Procedure	2
Behavioral	1
Biological|Drug|Other	1
Device|Drug	1
Device|Drug|Other|Procedure	1
Device|Other|Procedure	1
Drug|Other|Procedure|Radiation	1
Drug|Radiation	1
Genetic	1
Procedure|Radiation	1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country	Study_Count
United States	37
China	7
India	6
Brazil	5
Canada	4
Denmark	4
Korea, Republic of	4
Spain	4
United Kingdom	4
France	3
NA	3
Switzerland	3
Australia	2
Egypt	2
Germany	2
Israel	2
Italy	2
Nigeria	2
Slovenia	2
Taiwan	2
United States|United Kingdom	2
Belgium	1
Czechia	1
Finland	1
Greece	1
Singapore	1
Thailand	1
Turkey	1
United States|Canada	1

Sites per Study

Site_count	Study_Count
1	89
2	6
3	2
4	2
5	1
6	1
7	1
8	1
10	2
18	1
19	1
96	1
101	1
241	1

Phase

Phase	Study_Count
N/A	56
Phase 2	21
Phase 1	13
Phase 3	10
Phase 4	6
Early Phase 1	2
Phase 1/Phase 2	1
Phase 2/Phase 3	1

Number of Arms

Number_of_Arms	Count_of_Studies
1	29
2	65
3	5
4	2
5	1
NA	8

Enrollment Metrics by Phase

Measure	Early.Phase.1	N.A	Phase.1	Phase.1.Phase.2	Phase.2	Phase.2.Phase.3	Phase.3	Phase.4
Min.	4.00	4.0000	10.00000	24	4.00000	40	20.00	60.0000
1st Qu.	6.75	47.5000	15.00000	24	40.00000	40	61.75	70.0000
Median	9.50	100.0000	17.50000	24	55.00000	40	70.00	125.0000
Mean	9.50	131.2679	22.08333	24	73.47619	40	170.80	145.6667
3rd Qu.	12.25	142.0000	23.25000	24	68.00000	40	240.00	190.5000
Max.	15.00	1020.0000	62.00000	24	336.00000	40	501.00	300.0000

Trial Group Type

group_type	Group_Count
Experimental	96
Active Comparator	61
No Intervention	11
Other	11
NA	8
Placebo Comparator	7
Sham Comparator	1

Intervention Model

intervention_model	Study_Count
Parallel Assignment	59
Single Group Assignment	37
Crossover Assignment	5
Sequential Assignment	4
NA	4
Factorial Assignment	1

Primary Purpose

primary_purpose	Study_Count
Treatment	80
Diagnostic	14
Supportive Care	10
Prevention	4
Basic Science	1
Other	1

Observational Studies

Studies by Country

Country	Study_Count
United States	10
Germany	5
United Kingdom	4
China	3
NA	3
Canada	2
Denmark	2
Greece	2
France	1
Hong Kong	1
India	1
Israel	1
Italy	1
Singapore	1
Taiwan	1

Sites per Study

Site_count	Study_Count
1	32
2	4
3	1
12	1

Enrollment Metrics

Measure	Observational
Min	2.0000
1st Qu	60.0000
Median	139.0000
Mean	726.4211
3rd Qu	345.7500
Max	6909.0000

Observation Model

observational_model	Study_Count
Cohort	27
Case-Only	5
Case-Control	2
Other	2
NA	2

Time Perspective

time_perspective	Study_Count
Prospective	30
Retrospective	6
Cross-Sectional	2

Registries

Studies by Country

Country	Study_Count
Argentina|Australia|Austria|Belgium|Denmark|France|Germany|Italy|Poland|Russian Federation|Singapore|Spain|Switzerland	1
Germany	1
Hong Kong	1
Italy	1

Sites per Study

Site_count	Study_Count
1	3
16	1

Enrollment Metrics

Measure	Registries
Min	30.00
1st Qu	157.50
Median	216.50
Mean	365.75
3rd Qu	424.75
Max	1000.00

Registry Model

observational_model	Study_Count
Cohort	4

Time Perspective

time_perspective	Study_Count
Prospective	4

Follow-up

target_duration	Study_Count
1 Month	1
1 Year	1
3 Years	1
5 Days	1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT04438317	Thoracic Drains in Intensive Care Units: Comparison of Seldinger and Surgical Methods	https://ClinicalTrials.gov/show/NCT04438317	Recruiting	University Hospital, Clermont-Ferrand	2022-11-28
NCT04254445	Use of Guidance Videos to Increase Engagement and Decrease Anxiety in Patients Undergoing Pleural Tap	https://ClinicalTrials.gov/show/NCT04254445	Recruiting	GistMed Ltd.	2020-05-30
NCT03449602	Minirigid Versus Conventional Rigid Thoracoscopy in Undiagnosed Pleural Effusions	https://ClinicalTrials.gov/show/NCT03449602	Recruiting	Postgraduate Institute of Medical Education and Research	2020-02-28
NCT03327688	Point-of-care Ultrasound in Finland	https://ClinicalTrials.gov/show/NCT03327688	Recruiting	Kuopio University Hospital	2019-07-31
NCT03231072	Pleural Effusion Drainage in Mechanically Ventilated Patients Monitored by EIT	https://ClinicalTrials.gov/show/NCT03231072	Recruiting	Czech Technical University in Prague	2019-09-30
NCT03093610	Evaluation of Fluid Output Threshold for Safe Chest Tube Removal - A Potential Way to Decrease Length of Stay in Hospital and to Improve Postoperative Care After Lung Surgery?	https://ClinicalTrials.gov/show/NCT03093610	Recruiting	University Hospital Inselspital, Berne	2021-04-30
NCT03027180	Pressure Levels on Lung Expansion	https://ClinicalTrials.gov/show/NCT03027180	Completed	Universidade Cidade de Sao Paulo	2016-12-31
NCT02942043	Bevacizumab in the Treatment of Malignant Pleural Effusions of Non-squamous Non-small Cell Lung Cancer	https://ClinicalTrials.gov/show/NCT02942043	Recruiting	Beijing Cancer Hospital	2019-05-31
NCT02851927	Mini Thoracoscopy vs Semirigid Thoracoscopy in Exudative Pleural Effusions	https://ClinicalTrials.gov/show/NCT02851927	Completed	All India Institute of Medical Sciences, New Delhi	2018-07-31
NCT02674243	Efficacy of Iodopovidone Versus Talc in Palliative Malignant Pleural Effusion	https://ClinicalTrials.gov/show/NCT02674243	Completed	Chiang Mai University	2019-12-31
NCT02657460	Clinical Trial of Tumor Cell-derived Microparticles Packaging Chemotherapeutic Drugs to Treat Malignant Pleural Effusion	https://ClinicalTrials.gov/show/NCT02657460	Recruiting	Wuhan Union Hospital, China	2019-12-31
NCT02649894	Safety and Effectiveness of a New Pleural Catheter for Symptomatic, Recurrent, MPEs Versus Approved Pleural Catheter	https://ClinicalTrials.gov/show/NCT02649894	Completed	CareFusion	2018-04-18
NCT03869697	Study With SCB-313 (Recombinant Human TRAIL-Trimer Fusion Protein) for Treatment of Malignant Pleural Effusions	https://ClinicalTrials.gov/show/NCT03869697	Recruiting	Clover Biopharmaceuticals AUS Pty Ltd	2020-11-30
NCT02595567	Catheter Placement for Hepatic Hydrothorax	https://ClinicalTrials.gov/show/NCT02595567	Completed	Washington University School of Medicine	2015-07-20
NCT02583282	A Study to Compare the Efficacy and Safety of Intrapleural Doxycycline Versus Iodopovidone for Performing Pleurodesis in Malignant Pleural Effusion	https://ClinicalTrials.gov/show/NCT02583282	Recruiting	Postgraduate Institute of Medical Education and Research	2019-12-31
NCT03403855	Rocket® Pleural Catheters: QOL, Feasibility and Satisfaction in Recurrent MPE Patients	https://ClinicalTrials.gov/show/NCT03403855	Recruiting	Ottawa Hospital Research Institute	2019-12-30
NCT03394118	TAGRISSO (Osimertinib) in NSCLC Patients in Whom T790 Mutations Are Detected by Liquid Biopsy Using BALF, Plasma or Pleural Effusion	https://ClinicalTrials.gov/show/NCT03394118	Recruiting	Asan Medical Center	2020-12-31
NCT03394105	Intrapleural Docetaxel Administration Using Medical Pleuroscopy in Malignant Effusion With Lung Cancer	https://ClinicalTrials.gov/show/NCT03394105	Completed	Asan Medical Center	2018-06-22
NCT02517749	Out Patient Talc Slurry Via Indwelling Pleural Catheter for Malignant Pleural Effusion Vs Usual Inpatient Management	https://ClinicalTrials.gov/show/NCT02517749	Active, not recruiting	Guy’s and St Thomas’ NHS Foundation Trust	2019-12-27
NCT02505763	Thoracic Ultrasound in the Treatment of Pleural Effusion	https://ClinicalTrials.gov/show/NCT02505763	Recruiting	University Hospital, Toulouse	2019-12-31
NCT02500277	Yield of Cryoprobe vs Flexible Forceps Pleural Biopsy	https://ClinicalTrials.gov/show/NCT02500277	Completed	Postgraduate Institute of Medical Education and Research	2018-07-31
NCT02446782	Efficacy and Safety of Prophylactic Use of an Antibiotic for Medical Thoracoscopy	https://ClinicalTrials.gov/show/NCT02446782	Completed	Postgraduate Institute of Medical Education and Research	2016-04-30
NCT02359383	Impact of Respiratory Physiotherapy in the Management of Infectious Pleural Effusion	https://ClinicalTrials.gov/show/NCT02359383	Recruiting	Hospital de Granollers	2019-11-30
NCT02246946	Positive Airway Pressure on Pleural Effusion After Drainage	https://ClinicalTrials.gov/show/NCT02246946	Completed	Universidade Cidade de Sao Paulo	2014-12-31
NCT02227732	A Pilot Study Evaluating the Safety and Effectiveness of a New Pleural Catheter for the Medical Management of Symptomatic, Recurrent, Malignant Pleural Effusions	https://ClinicalTrials.gov/show/NCT02227732	Completed	CareFusion	2015-05-31
NCT02191540	Efficacy and Safety Study of Abnoba Viscum F 20mg in Malignant Pleural Effusion Patients	https://ClinicalTrials.gov/show/NCT02191540	Completed	Abnoba Korea	2013-01-31
NCT02165891	Comparison of Intrapleural Urokinase and Video-Assisted Thorascopic Surgery in the Treatment of Parapneumonic Pleural Effusion in Children	https://ClinicalTrials.gov/show/NCT02165891	Recruiting	Queen Fabiola Children’s University Hospital	2020-06-30
NCT02147821	Necessity of Using Pleural Drainage Tubes After IMA Harvesting During Cardiac Surgery	https://ClinicalTrials.gov/show/NCT02147821	Completed	University of Calgary	2017-11-30
NCT02135588	Combination Tissue Plasminogen Activator (Tpa) and Dornase Alfa (Dnase) Administration Through Intrapleural Catheters for the Treatment of Loculated or Non-Draining Malignant Pleural Effusions	https://ClinicalTrials.gov/show/NCT02135588	Recruiting	Eastern Regional Medical Center	2020-06-30
NCT02122185	Metformin and Chemotherapy in Treating Patients With Stage III-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer	https://ClinicalTrials.gov/show/NCT02122185	Recruiting	University of Chicago	2021-02-25
NCT02119169	Pigtail Catheter: a Less Invasive Option for Pleural Drainage of Recurrent Hepatic Hydrothorax	https://ClinicalTrials.gov/show/NCT02119169	Recruiting	Tanta University	2022-12-31
NCT02054052	Intrapleural Bevacizumab Injection for Malignant Effusion in Lung Cancer	https://ClinicalTrials.gov/show/NCT02054052	Completed	Guangzhou Medical University	2019-03-31
NCT02045641	Pleural and Pericardial Effusion Following Open Heart Surgery	https://ClinicalTrials.gov/show/NCT02045641	Completed	Aarhus University Hospital Skejby	2015-10-31
NCT02036398	Tubeless Versus Standard Upper Pole Percutaneous Nephrolithotomy	https://ClinicalTrials.gov/show/NCT02036398	Completed	Rabin Medical Center	2017-04-07
NCT03597009	A Study of Nivolumab and Intrapleural Talimogene Laherparepvec for Malignant Pleural Effusion	https://ClinicalTrials.gov/show/NCT03597009	Recruiting	UNC Lineberger Comprehensive Cancer Center	2020-12-30
NCT01997190	Intrapleural AdV-tk Therapy in Patients With Malignant Pleural Effusion	https://ClinicalTrials.gov/show/NCT01997190	Active, not recruiting	Advantagene, Inc.	2015-12-31
NCT01948076	Evaluation of a Pocket-Sized Ultrasound Device As an Aid to the Physical Examination	https://ClinicalTrials.gov/show/NCT01948076	Completed	Brigham and Women’s Hospital	2012-11-30
NCT01869504	A Feasibility and Safety Study of the Use of a Dedicated Ballooned Intercostal Drain	https://ClinicalTrials.gov/show/NCT01869504	Completed	Sherwood Forest Hospitals NHS Foundation Trust	2014-06-30
NCT01778270	Not Invasive Monitoring of Pleural Drainage	https://ClinicalTrials.gov/show/NCT01778270	Completed	RWTH Aachen University	2013-04-30
NCT01776372	Comparison of Pleural Drainage Systems on Reducing Pleural Effusion Formation Following Lung Resection	https://ClinicalTrials.gov/show/NCT01776372	Completed	McMaster University	2013-08-31
NCT01766739	Intra-pleural Administration of GL-ONC1, a Genetically Modified Vaccinia Virus, in Patients With Malignant Pleural Effusion: Primary, Metastases and Mesothelioma	https://ClinicalTrials.gov/show/NCT01766739	Active, not recruiting	Memorial Sloan Kettering Cancer Center	2021-01-31
NCT01756742	Effects of Respiratory Physiotherapy on Pleural Effusion	https://ClinicalTrials.gov/show/NCT01756742	Completed	Universidad de Granada	2011-01-31
NCT01726556	A Trial of Rigid Versus Semirigid Thoracoscopy in the Evaluation of Exudative Pleural Effusions	https://ClinicalTrials.gov/show/NCT01726556	Completed	Postgraduate Institute of Medical Education and Research	2012-12-31
NCT01722149	Re-directed T Cells for the Treatment (FAP)-Positive Malignant Pleural Mesothelioma	https://ClinicalTrials.gov/show/NCT01722149	Completed	University of Zurich	2019-03-22
NCT01673165	Fortified Skimmed Mother’s Milk in the Management of Chylothorax	https://ClinicalTrials.gov/show/NCT01673165	Completed	Oregon Health and Science University	2015-06-30
NCT01670786	Safety Profile of Iodopovidone as an Agent for Pleurodesis in Malignant Pleural Effusion	https://ClinicalTrials.gov/show/NCT01670786	Completed	Grupo de Pesquisa em Pleura e Oncologia Toracica	2013-07-31
NCT01661790	Intrapleural Bevacizumab and Cisplatin Therapy for Malignant Pleural Effusion Caused by Non-small Cell Lung Cancer	https://ClinicalTrials.gov/show/NCT01661790	Completed	Chinese PLA General Hospital	2012-06-30
NCT01475084	Cryobiopsy or Forceps Biopsy During Semirigid Thoracoscopy: a Comparative Study	https://ClinicalTrials.gov/show/NCT01475084	Completed	The University Clinic of Pulmonary and Allergic Diseases Golnik	2014-11-30
NCT01472172	Pleural Cryobiopsies During Semirigid Thoracoscopy: A New Technique	https://ClinicalTrials.gov/show/NCT01472172	Completed	The University Clinic of Pulmonary and Allergic Diseases Golnik	2013-11-30
NCT01469728	Comparison of Thoracoscopic Talc Pleurodesis by Thoracic Epidural or General Anesthesia	https://ClinicalTrials.gov/show/NCT01469728	Completed	University of Rome Tor Vergata	2010-09-30
NCT01416519	Physiotherapy Technique Decreases Respiratory Complications After Cardiac Operation	https://ClinicalTrials.gov/show/NCT01416519	Completed	Santa Casa de Votuporanga	2014-01-31
NCT01411202	Effectiveness of Doxycycline for Treating Pleural Effusions Related to Cancer in an Outpatient Population	https://ClinicalTrials.gov/show/NCT01411202	Recruiting	Ottawa Hospital Research Institute	2019-11-30
NCT01409551	Video-assisted Hyperthermic Pleural Chemoperfusion vs Talc Pleurodesis for Refractory Malignant Pleural Effusions.	https://ClinicalTrials.gov/show/NCT01409551	Completed	Theagenio Cancer Hospital	2014-11-30
NCT01327235	Endostar and/or Cisplatin for Treatment of Malignant Pleural Effusion or Ascites	https://ClinicalTrials.gov/show/NCT01327235	Completed	Jiangsu Simcere Pharmaceutical Co., Ltd.	2014-04-30
NCT04420663	Pleural Manometry in Thoracocentesis	https://ClinicalTrials.gov/show/NCT04420663	Recruiting	Ain Shams University	2020-12-31
NCT04322136	AMPLE-3: IPC Plus Talc vs VATS in Management of Malignant Pleural Effusion	https://ClinicalTrials.gov/show/NCT04322136	Recruiting	The University of Western Australia	2021-08-01
NCT04236037	Ultrasound-guided Biopsy of the Pleura as a Supplement to Extraction of Fluid in Patients With One-sided Fluid in the Pleura	https://ClinicalTrials.gov/show/NCT04236037	Recruiting	Naestved Hospital	2022-05-11
NCT04233359	A Randomised Study Evaluating Diagnostics of Pleural Effusion Among Patients Suspect of Cancer.	https://ClinicalTrials.gov/show/NCT04233359	Recruiting	Naestved Hospital	2021-12-20
NCT04193241	Suturing With U-Technique Versus Un-Reapproximated Wound Edges During Removal of Closed Thoracostomy Tube Drain	https://ClinicalTrials.gov/show/NCT04193241	Recruiting	University of Ibadan	2020-12-31
NCT04123886	A Phase I Study Evaluating SCB-313(Recombinant Human TRAIL-Trimer Fusion Protein) for the Treatment of Malignant Pleural Effusion	https://ClinicalTrials.gov/show/NCT04123886	Recruiting	Sichuan Clover Biopharmaceuticals, Inc.	2020-12-30
NCT04039126	Comparison of the Effectiveness of Povidone-Iodine Alone to Povidone-Iodine-Tetracycline Combination	https://ClinicalTrials.gov/show/NCT04039126	Recruiting	University College Hospital, Ibadan	2019-12-19
NCT03987087	A Randomized Study of Primary Tumor Radiotherapy for Patients With MPE Stage IV NSCLC	https://ClinicalTrials.gov/show/NCT03987087	Recruiting	Guizhou Medical University	2020-12-30
NCT03973957	Talc Outpatient Pleurodesis With Indwelling Catheter	https://ClinicalTrials.gov/show/NCT03973957	Recruiting	The Cooper Health System	2021-01-31
NCT03861897	Efficacy of Non-instrumental Pleural Chest Physiotherapy	https://ClinicalTrials.gov/show/NCT03861897	Recruiting	Centre Hospitalier René Dubos	2020-12-21
NCT03831386	Gravity Versus Vacuum Based Indwelling Tunneled Pleural Drainage System	https://ClinicalTrials.gov/show/NCT03831386	Recruiting	Johns Hopkins University	2022-12-31
NCT03728491	Education and Training Competences in Thoracic Ultrasound	https://ClinicalTrials.gov/show/NCT03728491	Recruiting	Odense University Hospital	2019-10-01
NCT03696524	Tunneled Pleural Catheters for Refractory Effusions Attributed to Congestive Heart Failure (TREAT-CHF) Trial	https://ClinicalTrials.gov/show/NCT03696524	Recruiting	University of California, Los Angeles	2020-05-01
NCT03591952	Gravity- Versus Suction-driven Large Volume Thoracentesis	https://ClinicalTrials.gov/show/NCT03591952	Completed	Vanderbilt University Medical Center	2019-04-05
NCT03550027	Indwelling Pleural Catheter for Trapped Lung	https://ClinicalTrials.gov/show/NCT03550027	Completed	European Institute of Oncology	2017-11-03
NCT03518788	Malignant Pleural Effusion: Pleur-X vs. Chemical Pleurodesis in VATS	https://ClinicalTrials.gov/show/NCT03518788	Recruiting	Ente Ospedaliero Cantonale, Bellinzona	2020-03-31
NCT03496987	Vacuum vs Manual Drainage During Unilateral Thoracentesis	https://ClinicalTrials.gov/show/NCT03496987	Completed	Yale University	2017-09-30
NCT03465774	Indwelling Pleural Catheters With or Without Doxycycline in Treating Patients With Malignant Pleural Effusions	https://ClinicalTrials.gov/show/NCT03465774	Recruiting	M.D. Anderson Cancer Center	2021-12-31
NCT03414905	Management of Malignant Pleural Effusions Using an Indwelling Tunneled Pleural Catheter and Non-Vacuum Collection System	https://ClinicalTrials.gov/show/NCT03414905	Recruiting	Washington University School of Medicine	2020-07-31
NCT03412357	MesoTRAP: A Study Comparing Video-assisted Thoracoscopic Partial Pleurectomy/Decortication With Indwelling Pleural Catheter in Patients With Trapped Lung Due to Malignant Pleural Mesothelioma.	https://ClinicalTrials.gov/show/NCT03412357	Recruiting	Papworth Hospital NHS Foundation Trust	2019-12-01
NCT01261546	Clinical Trial Corticoids For Empyema And Pleural Effusion In Children	https://ClinicalTrials.gov/show/NCT01261546	Completed	Hospital Infanta Sofia	2015-05-31
NCT01246453	Efficacy and Security of Intrapleurally Alteplase vs Urokinase for the Treatment of Complicated Parapneumonic Effusion and Empyema	https://ClinicalTrials.gov/show/NCT01246453	Completed	Hospital Universitari Vall d’Hebron Research Institute	2010-12-31
NCT01179685	Diagnostic Utility of Pleural Fluid MAGE Assay in Patients With Pleural Effusion From Primary Lung Cancer	https://ClinicalTrials.gov/show/NCT01179685	Completed	Samsung Medical Center	2010-12-31
NCT00978939	Impact of Aggressive Versus Standard Drainage Regimen Using a Long Term Indwelling Pleural Catheter	https://ClinicalTrials.gov/show/NCT00978939	Completed	Duke University	2013-03-31
NCT00896285	The First Therapeutic Intervention in Malignant Pleural Effusion Trial	https://ClinicalTrials.gov/show/NCT00896285	Completed	University of California, Davis	2014-12-31
NCT02677883	Impact of Pleural Manometry on Chest Discomfort After Therapeutic Thoracentesis	https://ClinicalTrials.gov/show/NCT02677883	Completed	Vanderbilt-Ingram Cancer Center	2017-10-26
NCT00789087	Talc Pleurodesis in Patients With Recurrent Malignant Pleural Effusion	https://ClinicalTrials.gov/show/NCT00789087	Completed	University of Sao Paulo	2008-01-31
NCT00720954	Rigid Thoracoscopy Versus CT-Guided Pleural Needle Biopsy	https://ClinicalTrials.gov/show/NCT00720954	Completed	Eskisehir Osmangazi University	2008-06-30
NCT00761618	Intrapleural Catheter Daily Versus Three Times a Week Drainage	https://ClinicalTrials.gov/show/NCT00761618	Active, not recruiting	M.D. Anderson Cancer Center	2020-03-31
NCT00758316	A Prospective, Randomized Controlled Trial for a Rapid Pleurodesis Protocol for the Management of Pleural Effusions	https://ClinicalTrials.gov/show/NCT00758316	Completed	Singapore General Hospital	2013-06-30
NCT00637676	Tunneled Pleural Catheter in Partially Entrapped Lung	https://ClinicalTrials.gov/show/NCT00637676	Completed	Heidelberg University	2011-06-30
NCT00629538	Therapeutic Thoracentesis for Patients With Congestive Heart Failure and Large Pleural Effusion	https://ClinicalTrials.gov/show/NCT00629538	Completed	Taipei Medical University Hospital	2009-07-31
NCT00575198	Drainage Amount for Removal of Thoracostomy Tube	https://ClinicalTrials.gov/show/NCT00575198	Completed	University of California, Davis	2012-09-30
NCT00564733	FDG-Labeled PET Scan in Planning Chemotherapy in Treating Patients With Stage IIIB or IV Non-Small Cell Lung Cancer	https://ClinicalTrials.gov/show/NCT00564733	Completed	University of Washington	2011-09-30
NCT00560521	Continuous Positive Airway Pressure on Tuberculosis Pleural Effusion	https://ClinicalTrials.gov/show/NCT00560521	Completed	Universidade Federal do Rio de Janeiro	NA
NCT00533585	BAY 43-9006 in Previously Untreated Patients With Non-Small Cell Lung Cancer (NSCLC)	https://ClinicalTrials.gov/show/NCT00533585	Completed	M.D. Anderson Cancer Center	2016-01-31
NCT00528645	AZD0530 in Treating Patients With Extensive Stage Small Cell Lung Cancer	https://ClinicalTrials.gov/show/NCT00528645	Completed	National Cancer Institute (NCI)	2008-11-30
NCT00524147	Drainage of Tuberculous Pleural Effusions	https://ClinicalTrials.gov/show/NCT00524147	Completed	Taipei Medical University Hospital	2005-10-31
NCT00468104	Efficacy and Safety of Activase (Ateplase) vs Placebo in Complicated Pleural Effusions (CPE)/Empyemas	https://ClinicalTrials.gov/show/NCT00468104	Completed	Midwest Pulmonary and Critical Care	2008-10-31
NCT00408460	Imatinib Mesylate and Paclitaxel in Treating Older Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer	https://ClinicalTrials.gov/show/NCT00408460	Completed	University of Washington	2010-08-31
NCT00299962	Gene Therapy for Pleural Malignancies	https://ClinicalTrials.gov/show/NCT00299962	Completed	University of Pennsylvania	2008-05-31
NCT00250978	Ph I:Bevacizumab + Chemotherapy in Pts w/Malig Pleural Effusion Due to Adv NSCLC	https://ClinicalTrials.gov/show/NCT00250978	Completed	Memorial Sloan Kettering Cancer Center	2008-04-30
NCT00247416	Effects of Carboplatin and Gemcitabine on Stage IIIB Pleural Effusion and Stage IV Lung Cancer	https://ClinicalTrials.gov/show/NCT00247416	Completed	University of Kentucky	2009-07-31
NCT00231465	Phase II Study of Docetaxel + ZD1839 in Elderly Patients With Non-Small Cell Lung Cancer	https://ClinicalTrials.gov/show/NCT00231465	Completed	H. Lee Moffitt Cancer Center and Research Institute	2012-08-31
NCT00215930	The ‘MADe IT’ Clinical Trial: Molecular Analyses Directed Individualized Therapy for Advanced Non-Small Cell Lung Cancer	https://ClinicalTrials.gov/show/NCT00215930	Completed	H. Lee Moffitt Cancer Center and Research Institute	2009-10-31
NCT00126581	Erlotinib Hydrochloride With or Without Carboplatin and Paclitaxel in Treating Patients With Stage III-IV Non-small Cell Lung Cancer	https://ClinicalTrials.gov/show/NCT00126581	Completed	National Cancer Institute (NCI)	2010-06-30
NCT00118183	Docetaxel With Either Cetuximab or Bortezomib as First-Line Therapy in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancer	https://ClinicalTrials.gov/show/NCT00118183	Completed	National Cancer Institute (NCI)	2007-04-30
NCT00114205	Surgery and Intrapleural Docetaxel in Treating Patients With Malignant Pleural Effusion	https://ClinicalTrials.gov/show/NCT00114205	Completed	National Cancer Institute (NCI)	NA
NCT00099541	Non-small Cell Lung Cancer Registry	https://ClinicalTrials.gov/show/NCT00099541	Completed	Novartis	NA
NCT00002872	Bleomycin, Doxycycline, or Talc in Treating Patients With Malignant Pleural Effusions	https://ClinicalTrials.gov/show/NCT00002872	Completed	Eastern Cooperative Oncology Group	2003-02-28
NCT00002622	Talc in Treating Patients With Malignant Pleural Effusion	https://ClinicalTrials.gov/show/NCT00002622	Completed	Alliance for Clinical Trials in Oncology	2005-03-31
NCT00004074	Interleukin-12 and Trastuzumab in Treating Patients With Cancer That Has High Levels of HER2/Neu	https://ClinicalTrials.gov/show/NCT00004074	Completed	National Cancer Institute (NCI)	2009-02-28
NCT00066404	Intrapleural BG00001 in Treating Patients With Malignant Pleural Mesothelioma or Malignant Pleural Effusions	https://ClinicalTrials.gov/show/NCT00066404	Completed	Abramson Cancer Center of the University of Pennsylvania	2006-01-31
NCT00052338	Bortezomib Plus Gemcitabine and Carboplatin in Treating Patients With Advanced or Recurrent Non-Small Cell Lung Cancer	https://ClinicalTrials.gov/show/NCT00052338	Completed	National Cancer Institute (NCI)	2004-05-31
NCT00042770	Standard Chest Tube Compared With a Small Catheter in Treating Malignant Pleural Effusion in Patients With Cancer	https://ClinicalTrials.gov/show/NCT00042770	Completed	Alliance for Clinical Trials in Oncology	2005-02-28
NCT00005906	Treatment With Octreotide in Patients With Lymphangioleiomyomatosis	https://ClinicalTrials.gov/show/NCT00005906	Completed	National Institutes of Health Clinical Center (CC)	2008-04-30

Observational Studiess

#If less then 500 studies

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT03409055	Pleural Effusions After Cardiac Surgery	https://ClinicalTrials.gov/show/NCT03409055	Completed	Charite University, Berlin, Germany	2013-12-31
NCT03394872	Impact of Draining Significant Effusion on Gas Exchange and Lung Mechanics in Patient Under Mechanical Ventilation	https://ClinicalTrials.gov/show/NCT03394872	Completed	Dokuz Eylul University	2017-08-30
NCT03379688	PDMS Outcome After Intensive Care, Organdysfunction and Monitoring	https://ClinicalTrials.gov/show/NCT03379688	Completed	Charite University, Berlin, Germany	2013-12-31
NCT03319472	Using Pleural Effusions to Diagnose Cancer	https://ClinicalTrials.gov/show/NCT03319472	Completed	University of Patras	2017-11-21
NCT03296280	Evaluation of Implementation of a National Point-of-Care Ultrasound Training Program	https://ClinicalTrials.gov/show/NCT03296280	Enrolling by invitation	VA Office of Research and Development	2018-06-29
NCT03235999	The Experiences of Patients Living With Malignant Pleural Effusions	https://ClinicalTrials.gov/show/NCT03235999	Recruiting	Gloucestershire Hospitals NHS Foundation Trust	2019-01-31
NCT02891642	Liquid Biopsy With Immunomagnetic Beads Capture Technique for Malignant Cell Detection in Body Fluid	https://ClinicalTrials.gov/show/NCT02891642	Recruiting	The First Affiliated Hospital with Nanjing Medical University	2021-02-28
NCT02625675	Using Thoracic Ultrasound to Predict Pleurodesis Success in Malignant Pleural Effusions: a Pilot Study	https://ClinicalTrials.gov/show/NCT02625675	Completed	University of Oxford	2017-07-06
NCT02546791	Frequency and Severity of Pleural Effusion Associated With the Use of Dasatinib in Patients With Chronic Myeloid Leukemia. A Descriptive, Mexican Multicenter Study	https://ClinicalTrials.gov/show/NCT02546791	Completed	Bristol-Myers Squibb	2016-11-30
NCT02419196	Perioperative Change of Regional Ventilation During Spontaneous Breathing	https://ClinicalTrials.gov/show/NCT02419196	Completed	Wuerzburg University Hospital	2016-02-29
NCT02232841	Electrical Impedance Imaging of Patients on Mechanical Ventilation	https://ClinicalTrials.gov/show/NCT02232841	Completed	Colorado State University	2016-08-31
NCT02208895	iSTAT Comparison Study, IRB3785	https://ClinicalTrials.gov/show/NCT02208895	Completed	University of Oklahoma	2019-08-28
NCT02104479	Diagnostic Accuracy of Pleural Effusion Aspergillosis Biomarker Testing	https://ClinicalTrials.gov/show/NCT02104479	Enrolling by invitation	Heidelberg University	2020-12-31
NCT02092155	Biomarker Levels During Indwelling Pleural cAtheter Sample Testing	https://ClinicalTrials.gov/show/NCT02092155	Enrolling by invitation	Johns Hopkins University	2020-12-31
NCT01902030	Evaluation of Performance of An Aspergillus PCR in Tissue and Pleural Effusion Samples of Immunocompromised Patients	https://ClinicalTrials.gov/show/NCT01902030	Enrolling by invitation	Heidelberg University	2020-12-31
NCT01616264	Reproducibility of Computed Tomography	https://ClinicalTrials.gov/show/NCT01616264	Completed	Universidade Federal do Rio de Janeiro	2009-10-31
NCT01560078	Efficacy Study of Thrice Weekly Directly Observed Treatment Short-Course Regimen in Tubercular Pleural Effusion	https://ClinicalTrials.gov/show/NCT01560078	Completed	All India Institute of Medical Sciences, New Delhi	2011-10-31
NCT01374542	Respiratory Endoscopy: Diagnostic Yield, Technical Factors and Complications	https://ClinicalTrials.gov/show/NCT01374542	Recruiting	Singapore General Hospital	2020-05-31
NCT04236934	Thoracentesis: Symptoms and Prediction of the Need for Therapeutic Thoracentesis	https://ClinicalTrials.gov/show/NCT04236934	Recruiting	Naestved Hospital	2021-08-13
NCT04235998	Value of Additional Upfront Systematic Lung Ultrasound in the Workup of Patients With Unilateral Pleural Effusion	https://ClinicalTrials.gov/show/NCT04235998	Recruiting	Naestved Hospital	2021-08-06
NCT03997669	The Diagnosis and Mechanism of Pleural Effusion	https://ClinicalTrials.gov/show/NCT03997669	Active, not recruiting	Wuhan Union Hospital, China	2020-02-01
NCT03846934	Positive and Quantitative Diagnosis of Pleural Effusions by Thoracic Ultrasonography in Patients With Acute Respiratory Failure in the Emergency Department	https://ClinicalTrials.gov/show/NCT03846934	Recruiting	University Hospital, Limoges	2021-04-14
NCT03737695	Clinical Information and Biospecimen Collection From Patients With Recurrent or Stage IV Breast Cancer	https://ClinicalTrials.gov/show/NCT03737695	Recruiting	Mayo Clinic	2020-11-05
NCT03661801	Novel Pleural Fluid, Biopsy and Serum Biomarkers for the Investigation of Pleural Effusions	https://ClinicalTrials.gov/show/NCT03661801	Recruiting	University of Oxford	2021-09-25
NCT03656822	Data Visualization of Kidney and Prostate Tumors Using Routine Pre-Operative Imaging, 3D Printed, and 3D Virtual Reality Models	https://ClinicalTrials.gov/show/NCT03656822	Completed	NYU Langone Health	2019-12-31
NCT03535883	The Safety of Thoracentesis, Tunneled Pleural Catheter, and Chest Tubes in Patients Taking Novel Oral Anti-Coagulants	https://ClinicalTrials.gov/show/NCT03535883	Recruiting	Yale University	2020-09-30
NCT03482570	Activity Behaviours in Patients With Malignant Pleural Effusion	https://ClinicalTrials.gov/show/NCT03482570	Recruiting	The University of Hong Kong	2019-12-31
NCT01256801	Gene Expression Profiling of Breast Cancer Cells Predict the Response of Malignant Pleural Effusion	https://ClinicalTrials.gov/show/NCT01256801	Completed	Beijing Cancer Hospital	2013-01-31
NCT01178580	Procoagulant Activity in Patients With Community Acquired Pneumonia, Pleural Effusion and Empyema	https://ClinicalTrials.gov/show/NCT01178580	Completed	Meir Medical Center	2011-08-31
NCT01117740	Pleural Catheters Versus Thoracoscopic Pleurodesis	https://ClinicalTrials.gov/show/NCT01117740	Completed	M.D. Anderson Cancer Center	2016-04-30
NCT01104285	Chest Tube Drainage of Transudative Pleural Effusions Hastens Liberation From Mechanical Ventilation	https://ClinicalTrials.gov/show/NCT01104285	Completed	Maimonides Medical Center	2010-04-30
NCT00915161	Sustained Effects of Thoracocentesis in Mechanically Ventilated Patients	https://ClinicalTrials.gov/show/NCT00915161	Completed	Oxford University Hospitals NHS Trust	2008-08-31
NCT03597828	Respiratory Function of Dexmedetomidine in Patients Undergoing Pleuroscopy	https://ClinicalTrials.gov/show/NCT03597828	Completed	Attikon Hospital	2020-06-30
NCT00665015	Pleural Effusion Following Cardiac Surgery: Prevalence, Risk Factors and Clinical Features	https://ClinicalTrials.gov/show/NCT00665015	Completed	Laval University	2005-12-31
NCT00646490	Pleural Fluid and Serum Procalcitonin in Patients With Parapneumonic Pleural Effusion	https://ClinicalTrials.gov/show/NCT00646490	Completed	Chang Gung Memorial Hospital	2009-07-31
NCT00473291	Vibration Response Imaging (VRI) in Management and Evaluation in Patients With Pleural Effusion	https://ClinicalTrials.gov/show/NCT00473291	Completed	Deep Breeze	NA
NCT00258518	Respiratory Mechanics and Pleural Effusion	https://ClinicalTrials.gov/show/NCT00258518	Completed	Policlinico Hospital	2011-06-30
NCT00188474	A Quality of Life Study re Management of Malignant Pleural Effusions	https://ClinicalTrials.gov/show/NCT00188474	Completed	University Health Network, Toronto	2013-11-30

Registries

#If less then 500 registries

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT03276715	Prognostic Factors on Malignant Pleural Effusion	https://ClinicalTrials.gov/show/NCT03276715	Completed	The University of Hong Kong	2018-10-01
NCT03210298	International Registry of Patients Treated With Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC)	https://ClinicalTrials.gov/show/NCT03210298	Recruiting	University of Magdeburg	2022-09-30
NCT03189654	Noninvasive Ventilation Therapy for the Treatment of Pleural Effusion in Patients With Heart Failure	https://ClinicalTrials.gov/show/NCT03189654	Recruiting	Heart and Diabetes Center North-Rhine Westfalia	2019-12-31
NCT03064659	Driving Pressure And EFL in Adult Cardiac Surgery	https://ClinicalTrials.gov/show/NCT03064659	Completed	Ospedale San Raffaele	2017-01-31