Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html


Study Counts

Type Study_count
Total_Studies 152
interventional 110
Observational 38
Registry 4

Studies over Time by Start Date

```

Interventional Trials

Intervention Type

intervention_type Study_Count
Drug 25
Procedure 23
Device 22
Other 10
Biological 5
Drug|Other 3
Drug|placebo 3
Biological|Drug 2
Device|Procedure 2
Diagnostic Test 2
Drug|Procedure 2
Other|Procedure 2
Behavioral 1
Biological|Drug|Other 1
Device|Drug 1
Device|Drug|Other|Procedure 1
Device|Other|Procedure 1
Drug|Other|Procedure|Radiation 1
Drug|Radiation 1
Genetic 1
Procedure|Radiation 1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country Study_Count
United States 37
China 7
India 6
Brazil 5
Canada 4
Denmark 4
Korea, Republic of 4
Spain 4
United Kingdom 4
France 3
NA 3
Switzerland 3
Australia 2
Egypt 2
Germany 2
Israel 2
Italy 2
Nigeria 2
Slovenia 2
Taiwan 2
United States|United Kingdom 2
Belgium 1
Czechia 1
Finland 1
Greece 1
Singapore 1
Thailand 1
Turkey 1
United States|Canada 1

Sites per Study

Site_count Study_Count
1 89
2 6
3 2
4 2
5 1
6 1
7 1
8 1
10 2
18 1
19 1
96 1
101 1
241 1

Phase

Phase Study_Count
N/A 56
Phase 2 21
Phase 1 13
Phase 3 10
Phase 4 6
Early Phase 1 2
Phase 1/Phase 2 1
Phase 2/Phase 3 1

Number of Arms

Number_of_Arms Count_of_Studies
1 29
2 65
3 5
4 2
5 1
NA 8

Enrollment Metrics by Phase

Measure Early.Phase.1 N.A Phase.1 Phase.1.Phase.2 Phase.2 Phase.2.Phase.3 Phase.3 Phase.4
Min. 4.00 4.0000 10.00000 24 4.00000 40 20.00 60.0000
1st Qu. 6.75 47.5000 15.00000 24 40.00000 40 61.75 70.0000
Median 9.50 100.0000 17.50000 24 55.00000 40 70.00 125.0000
Mean 9.50 131.2679 22.08333 24 73.47619 40 170.80 145.6667
3rd Qu. 12.25 142.0000 23.25000 24 68.00000 40 240.00 190.5000
Max. 15.00 1020.0000 62.00000 24 336.00000 40 501.00 300.0000

Trial Group Type

group_type Group_Count
Experimental 96
Active Comparator 61
No Intervention 11
Other 11
NA 8
Placebo Comparator 7
Sham Comparator 1

Intervention Model

intervention_model Study_Count
Parallel Assignment 59
Single Group Assignment 37
Crossover Assignment 5
Sequential Assignment 4
NA 4
Factorial Assignment 1

Primary Purpose

primary_purpose Study_Count
Treatment 80
Diagnostic 14
Supportive Care 10
Prevention 4
Basic Science 1
Other 1

Observational Studies

Studies by Country

Country Study_Count
United States 10
Germany 5
United Kingdom 4
China 3
NA 3
Canada 2
Denmark 2
Greece 2
France 1
Hong Kong 1
India 1
Israel 1
Italy 1
Singapore 1
Taiwan 1

Sites per Study

Site_count Study_Count
1 32
2 4
3 1
12 1

Enrollment Metrics

Measure Observational
Min 2.0000
1st Qu 60.0000
Median 139.0000
Mean 726.4211
3rd Qu 345.7500
Max 6909.0000

Observation Model

observational_model Study_Count
Cohort 27
Case-Only 5
Case-Control 2
Other 2
NA 2

Time Perspective

time_perspective Study_Count
Prospective 30
Retrospective 6
Cross-Sectional 2

Registries

Studies by Country

Country Study_Count
Argentina|Australia|Austria|Belgium|Denmark|France|Germany|Italy|Poland|Russian Federation|Singapore|Spain|Switzerland 1
Germany 1
Hong Kong 1
Italy 1

Sites per Study

Site_count Study_Count
1 3
16 1

Enrollment Metrics

Measure Registries
Min 30.00
1st Qu 157.50
Median 216.50
Mean 365.75
3rd Qu 424.75
Max 1000.00

Registry Model

observational_model Study_Count
Cohort 4

Time Perspective

time_perspective Study_Count
Prospective 4

Follow-up

target_duration Study_Count
1 Month 1
1 Year 1
3 Years 1
5 Days 1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id brief_title link overall_status source primary_completion_date
NCT04438317 Thoracic Drains in Intensive Care Units: Comparison of Seldinger and Surgical Methods https://ClinicalTrials.gov/show/NCT04438317 Recruiting University Hospital, Clermont-Ferrand 2022-11-28
NCT04254445 Use of Guidance Videos to Increase Engagement and Decrease Anxiety in Patients Undergoing Pleural Tap https://ClinicalTrials.gov/show/NCT04254445 Recruiting GistMed Ltd. 2020-05-30
NCT03449602 Minirigid Versus Conventional Rigid Thoracoscopy in Undiagnosed Pleural Effusions https://ClinicalTrials.gov/show/NCT03449602 Recruiting Postgraduate Institute of Medical Education and Research 2020-02-28
NCT03327688 Point-of-care Ultrasound in Finland https://ClinicalTrials.gov/show/NCT03327688 Recruiting Kuopio University Hospital 2019-07-31
NCT03231072 Pleural Effusion Drainage in Mechanically Ventilated Patients Monitored by EIT https://ClinicalTrials.gov/show/NCT03231072 Recruiting Czech Technical University in Prague 2019-09-30
NCT03093610 Evaluation of Fluid Output Threshold for Safe Chest Tube Removal - A Potential Way to Decrease Length of Stay in Hospital and to Improve Postoperative Care After Lung Surgery? https://ClinicalTrials.gov/show/NCT03093610 Recruiting University Hospital Inselspital, Berne 2021-04-30
NCT03027180 Pressure Levels on Lung Expansion https://ClinicalTrials.gov/show/NCT03027180 Completed Universidade Cidade de Sao Paulo 2016-12-31
NCT02942043 Bevacizumab in the Treatment of Malignant Pleural Effusions of Non-squamous Non-small Cell Lung Cancer https://ClinicalTrials.gov/show/NCT02942043 Recruiting Beijing Cancer Hospital 2019-05-31
NCT02851927 Mini Thoracoscopy vs Semirigid Thoracoscopy in Exudative Pleural Effusions https://ClinicalTrials.gov/show/NCT02851927 Completed All India Institute of Medical Sciences, New Delhi 2018-07-31
NCT02674243 Efficacy of Iodopovidone Versus Talc in Palliative Malignant Pleural Effusion https://ClinicalTrials.gov/show/NCT02674243 Completed Chiang Mai University 2019-12-31
NCT02657460 Clinical Trial of Tumor Cell-derived Microparticles Packaging Chemotherapeutic Drugs to Treat Malignant Pleural Effusion https://ClinicalTrials.gov/show/NCT02657460 Recruiting Wuhan Union Hospital, China 2019-12-31
NCT02649894 Safety and Effectiveness of a New Pleural Catheter for Symptomatic, Recurrent, MPEs Versus Approved Pleural Catheter https://ClinicalTrials.gov/show/NCT02649894 Completed CareFusion 2018-04-18
NCT03869697 Study With SCB-313 (Recombinant Human TRAIL-Trimer Fusion Protein) for Treatment of Malignant Pleural Effusions https://ClinicalTrials.gov/show/NCT03869697 Recruiting Clover Biopharmaceuticals AUS Pty Ltd 2020-11-30
NCT02595567 Catheter Placement for Hepatic Hydrothorax https://ClinicalTrials.gov/show/NCT02595567 Completed Washington University School of Medicine 2015-07-20
NCT02583282 A Study to Compare the Efficacy and Safety of Intrapleural Doxycycline Versus Iodopovidone for Performing Pleurodesis in Malignant Pleural Effusion https://ClinicalTrials.gov/show/NCT02583282 Recruiting Postgraduate Institute of Medical Education and Research 2019-12-31
NCT03403855 Rocket® Pleural Catheters: QOL, Feasibility and Satisfaction in Recurrent MPE Patients https://ClinicalTrials.gov/show/NCT03403855 Recruiting Ottawa Hospital Research Institute 2019-12-30
NCT03394118 TAGRISSO (Osimertinib) in NSCLC Patients in Whom T790 Mutations Are Detected by Liquid Biopsy Using BALF, Plasma or Pleural Effusion https://ClinicalTrials.gov/show/NCT03394118 Recruiting Asan Medical Center 2020-12-31
NCT03394105 Intrapleural Docetaxel Administration Using Medical Pleuroscopy in Malignant Effusion With Lung Cancer https://ClinicalTrials.gov/show/NCT03394105 Completed Asan Medical Center 2018-06-22
NCT02517749 Out Patient Talc Slurry Via Indwelling Pleural Catheter for Malignant Pleural Effusion Vs Usual Inpatient Management https://ClinicalTrials.gov/show/NCT02517749 Active, not recruiting Guy’s and St Thomas’ NHS Foundation Trust 2019-12-27
NCT02505763 Thoracic Ultrasound in the Treatment of Pleural Effusion https://ClinicalTrials.gov/show/NCT02505763 Recruiting University Hospital, Toulouse 2019-12-31
NCT02500277 Yield of Cryoprobe vs Flexible Forceps Pleural Biopsy https://ClinicalTrials.gov/show/NCT02500277 Completed Postgraduate Institute of Medical Education and Research 2018-07-31
NCT02446782 Efficacy and Safety of Prophylactic Use of an Antibiotic for Medical Thoracoscopy https://ClinicalTrials.gov/show/NCT02446782 Completed Postgraduate Institute of Medical Education and Research 2016-04-30
NCT02359383 Impact of Respiratory Physiotherapy in the Management of Infectious Pleural Effusion https://ClinicalTrials.gov/show/NCT02359383 Recruiting Hospital de Granollers 2019-11-30
NCT02246946 Positive Airway Pressure on Pleural Effusion After Drainage https://ClinicalTrials.gov/show/NCT02246946 Completed Universidade Cidade de Sao Paulo 2014-12-31
NCT02227732 A Pilot Study Evaluating the Safety and Effectiveness of a New Pleural Catheter for the Medical Management of Symptomatic, Recurrent, Malignant Pleural Effusions https://ClinicalTrials.gov/show/NCT02227732 Completed CareFusion 2015-05-31
NCT02191540 Efficacy and Safety Study of Abnoba Viscum F 20mg in Malignant Pleural Effusion Patients https://ClinicalTrials.gov/show/NCT02191540 Completed Abnoba Korea 2013-01-31
NCT02165891 Comparison of Intrapleural Urokinase and Video-Assisted Thorascopic Surgery in the Treatment of Parapneumonic Pleural Effusion in Children https://ClinicalTrials.gov/show/NCT02165891 Recruiting Queen Fabiola Children’s University Hospital 2020-06-30
NCT02147821 Necessity of Using Pleural Drainage Tubes After IMA Harvesting During Cardiac Surgery https://ClinicalTrials.gov/show/NCT02147821 Completed University of Calgary 2017-11-30
NCT02135588 Combination Tissue Plasminogen Activator (Tpa) and Dornase Alfa (Dnase) Administration Through Intrapleural Catheters for the Treatment of Loculated or Non-Draining Malignant Pleural Effusions https://ClinicalTrials.gov/show/NCT02135588 Recruiting Eastern Regional Medical Center 2020-06-30
NCT02122185 Metformin and Chemotherapy in Treating Patients With Stage III-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer https://ClinicalTrials.gov/show/NCT02122185 Recruiting University of Chicago 2021-02-25
NCT02119169 Pigtail Catheter: a Less Invasive Option for Pleural Drainage of Recurrent Hepatic Hydrothorax https://ClinicalTrials.gov/show/NCT02119169 Recruiting Tanta University 2022-12-31
NCT02054052 Intrapleural Bevacizumab Injection for Malignant Effusion in Lung Cancer https://ClinicalTrials.gov/show/NCT02054052 Completed Guangzhou Medical University 2019-03-31
NCT02045641 Pleural and Pericardial Effusion Following Open Heart Surgery https://ClinicalTrials.gov/show/NCT02045641 Completed Aarhus University Hospital Skejby 2015-10-31
NCT02036398 Tubeless Versus Standard Upper Pole Percutaneous Nephrolithotomy https://ClinicalTrials.gov/show/NCT02036398 Completed Rabin Medical Center 2017-04-07
NCT03597009 A Study of Nivolumab and Intrapleural Talimogene Laherparepvec for Malignant Pleural Effusion https://ClinicalTrials.gov/show/NCT03597009 Recruiting UNC Lineberger Comprehensive Cancer Center 2020-12-30
NCT01997190 Intrapleural AdV-tk Therapy in Patients With Malignant Pleural Effusion https://ClinicalTrials.gov/show/NCT01997190 Active, not recruiting Advantagene, Inc. 2015-12-31
NCT01948076 Evaluation of a Pocket-Sized Ultrasound Device As an Aid to the Physical Examination https://ClinicalTrials.gov/show/NCT01948076 Completed Brigham and Women’s Hospital 2012-11-30
NCT01869504 A Feasibility and Safety Study of the Use of a Dedicated Ballooned Intercostal Drain https://ClinicalTrials.gov/show/NCT01869504 Completed Sherwood Forest Hospitals NHS Foundation Trust 2014-06-30
NCT01778270 Not Invasive Monitoring of Pleural Drainage https://ClinicalTrials.gov/show/NCT01778270 Completed RWTH Aachen University 2013-04-30
NCT01776372 Comparison of Pleural Drainage Systems on Reducing Pleural Effusion Formation Following Lung Resection https://ClinicalTrials.gov/show/NCT01776372 Completed McMaster University 2013-08-31
NCT01766739 Intra-pleural Administration of GL-ONC1, a Genetically Modified Vaccinia Virus, in Patients With Malignant Pleural Effusion: Primary, Metastases and Mesothelioma https://ClinicalTrials.gov/show/NCT01766739 Active, not recruiting Memorial Sloan Kettering Cancer Center 2021-01-31
NCT01756742 Effects of Respiratory Physiotherapy on Pleural Effusion https://ClinicalTrials.gov/show/NCT01756742 Completed Universidad de Granada 2011-01-31
NCT01726556 A Trial of Rigid Versus Semirigid Thoracoscopy in the Evaluation of Exudative Pleural Effusions https://ClinicalTrials.gov/show/NCT01726556 Completed Postgraduate Institute of Medical Education and Research 2012-12-31
NCT01722149 Re-directed T Cells for the Treatment (FAP)-Positive Malignant Pleural Mesothelioma https://ClinicalTrials.gov/show/NCT01722149 Completed University of Zurich 2019-03-22
NCT01673165 Fortified Skimmed Mother’s Milk in the Management of Chylothorax https://ClinicalTrials.gov/show/NCT01673165 Completed Oregon Health and Science University 2015-06-30
NCT01670786 Safety Profile of Iodopovidone as an Agent for Pleurodesis in Malignant Pleural Effusion https://ClinicalTrials.gov/show/NCT01670786 Completed Grupo de Pesquisa em Pleura e Oncologia Toracica 2013-07-31
NCT01661790 Intrapleural Bevacizumab and Cisplatin Therapy for Malignant Pleural Effusion Caused by Non-small Cell Lung Cancer https://ClinicalTrials.gov/show/NCT01661790 Completed Chinese PLA General Hospital 2012-06-30
NCT01475084 Cryobiopsy or Forceps Biopsy During Semirigid Thoracoscopy: a Comparative Study https://ClinicalTrials.gov/show/NCT01475084 Completed The University Clinic of Pulmonary and Allergic Diseases Golnik 2014-11-30
NCT01472172 Pleural Cryobiopsies During Semirigid Thoracoscopy: A New Technique https://ClinicalTrials.gov/show/NCT01472172 Completed The University Clinic of Pulmonary and Allergic Diseases Golnik 2013-11-30
NCT01469728 Comparison of Thoracoscopic Talc Pleurodesis by Thoracic Epidural or General Anesthesia https://ClinicalTrials.gov/show/NCT01469728 Completed University of Rome Tor Vergata 2010-09-30
NCT01416519 Physiotherapy Technique Decreases Respiratory Complications After Cardiac Operation https://ClinicalTrials.gov/show/NCT01416519 Completed Santa Casa de Votuporanga 2014-01-31
NCT01411202 Effectiveness of Doxycycline for Treating Pleural Effusions Related to Cancer in an Outpatient Population https://ClinicalTrials.gov/show/NCT01411202 Recruiting Ottawa Hospital Research Institute 2019-11-30
NCT01409551 Video-assisted Hyperthermic Pleural Chemoperfusion vs Talc Pleurodesis for Refractory Malignant Pleural Effusions. https://ClinicalTrials.gov/show/NCT01409551 Completed Theagenio Cancer Hospital 2014-11-30
NCT01327235 Endostar and/or Cisplatin for Treatment of Malignant Pleural Effusion or Ascites https://ClinicalTrials.gov/show/NCT01327235 Completed Jiangsu Simcere Pharmaceutical Co., Ltd. 2014-04-30
NCT04420663 Pleural Manometry in Thoracocentesis https://ClinicalTrials.gov/show/NCT04420663 Recruiting Ain Shams University 2020-12-31
NCT04322136 AMPLE-3: IPC Plus Talc vs VATS in Management of Malignant Pleural Effusion https://ClinicalTrials.gov/show/NCT04322136 Recruiting The University of Western Australia 2021-08-01
NCT04236037 Ultrasound-guided Biopsy of the Pleura as a Supplement to Extraction of Fluid in Patients With One-sided Fluid in the Pleura https://ClinicalTrials.gov/show/NCT04236037 Recruiting Naestved Hospital 2022-05-11
NCT04233359 A Randomised Study Evaluating Diagnostics of Pleural Effusion Among Patients Suspect of Cancer. https://ClinicalTrials.gov/show/NCT04233359 Recruiting Naestved Hospital 2021-12-20
NCT04193241 Suturing With U-Technique Versus Un-Reapproximated Wound Edges During Removal of Closed Thoracostomy Tube Drain https://ClinicalTrials.gov/show/NCT04193241 Recruiting University of Ibadan 2020-12-31
NCT04123886 A Phase I Study Evaluating SCB-313(Recombinant Human TRAIL-Trimer Fusion Protein) for the Treatment of Malignant Pleural Effusion https://ClinicalTrials.gov/show/NCT04123886 Recruiting Sichuan Clover Biopharmaceuticals, Inc. 2020-12-30
NCT04039126 Comparison of the Effectiveness of Povidone-Iodine Alone to Povidone-Iodine-Tetracycline Combination https://ClinicalTrials.gov/show/NCT04039126 Recruiting University College Hospital, Ibadan 2019-12-19
NCT03987087 A Randomized Study of Primary Tumor Radiotherapy for Patients With MPE Stage IV NSCLC https://ClinicalTrials.gov/show/NCT03987087 Recruiting Guizhou Medical University 2020-12-30
NCT03973957 Talc Outpatient Pleurodesis With Indwelling Catheter https://ClinicalTrials.gov/show/NCT03973957 Recruiting The Cooper Health System 2021-01-31
NCT03861897 Efficacy of Non-instrumental Pleural Chest Physiotherapy https://ClinicalTrials.gov/show/NCT03861897 Recruiting Centre Hospitalier René Dubos 2020-12-21
NCT03831386 Gravity Versus Vacuum Based Indwelling Tunneled Pleural Drainage System https://ClinicalTrials.gov/show/NCT03831386 Recruiting Johns Hopkins University 2022-12-31
NCT03728491 Education and Training Competences in Thoracic Ultrasound https://ClinicalTrials.gov/show/NCT03728491 Recruiting Odense University Hospital 2019-10-01
NCT03696524 Tunneled Pleural Catheters for Refractory Effusions Attributed to Congestive Heart Failure (TREAT-CHF) Trial https://ClinicalTrials.gov/show/NCT03696524 Recruiting University of California, Los Angeles 2020-05-01
NCT03591952 Gravity- Versus Suction-driven Large Volume Thoracentesis https://ClinicalTrials.gov/show/NCT03591952 Completed Vanderbilt University Medical Center 2019-04-05
NCT03550027 Indwelling Pleural Catheter for Trapped Lung https://ClinicalTrials.gov/show/NCT03550027 Completed European Institute of Oncology 2017-11-03
NCT03518788 Malignant Pleural Effusion: Pleur-X vs. Chemical Pleurodesis in VATS https://ClinicalTrials.gov/show/NCT03518788 Recruiting Ente Ospedaliero Cantonale, Bellinzona 2020-03-31
NCT03496987 Vacuum vs Manual Drainage During Unilateral Thoracentesis https://ClinicalTrials.gov/show/NCT03496987 Completed Yale University 2017-09-30
NCT03465774 Indwelling Pleural Catheters With or Without Doxycycline in Treating Patients With Malignant Pleural Effusions https://ClinicalTrials.gov/show/NCT03465774 Recruiting M.D. Anderson Cancer Center 2021-12-31
NCT03414905 Management of Malignant Pleural Effusions Using an Indwelling Tunneled Pleural Catheter and Non-Vacuum Collection System https://ClinicalTrials.gov/show/NCT03414905 Recruiting Washington University School of Medicine 2020-07-31
NCT03412357 MesoTRAP: A Study Comparing Video-assisted Thoracoscopic Partial Pleurectomy/Decortication With Indwelling Pleural Catheter in Patients With Trapped Lung Due to Malignant Pleural Mesothelioma. https://ClinicalTrials.gov/show/NCT03412357 Recruiting Papworth Hospital NHS Foundation Trust 2019-12-01
NCT01261546 Clinical Trial Corticoids For Empyema And Pleural Effusion In Children https://ClinicalTrials.gov/show/NCT01261546 Completed Hospital Infanta Sofia 2015-05-31
NCT01246453 Efficacy and Security of Intrapleurally Alteplase vs Urokinase for the Treatment of Complicated Parapneumonic Effusion and Empyema https://ClinicalTrials.gov/show/NCT01246453 Completed Hospital Universitari Vall d’Hebron Research Institute 2010-12-31
NCT01179685 Diagnostic Utility of Pleural Fluid MAGE Assay in Patients With Pleural Effusion From Primary Lung Cancer https://ClinicalTrials.gov/show/NCT01179685 Completed Samsung Medical Center 2010-12-31
NCT00978939 Impact of Aggressive Versus Standard Drainage Regimen Using a Long Term Indwelling Pleural Catheter https://ClinicalTrials.gov/show/NCT00978939 Completed Duke University 2013-03-31
NCT00896285 The First Therapeutic Intervention in Malignant Pleural Effusion Trial https://ClinicalTrials.gov/show/NCT00896285 Completed University of California, Davis 2014-12-31
NCT02677883 Impact of Pleural Manometry on Chest Discomfort After Therapeutic Thoracentesis https://ClinicalTrials.gov/show/NCT02677883 Completed Vanderbilt-Ingram Cancer Center 2017-10-26
NCT00789087 Talc Pleurodesis in Patients With Recurrent Malignant Pleural Effusion https://ClinicalTrials.gov/show/NCT00789087 Completed University of Sao Paulo 2008-01-31
NCT00720954 Rigid Thoracoscopy Versus CT-Guided Pleural Needle Biopsy https://ClinicalTrials.gov/show/NCT00720954 Completed Eskisehir Osmangazi University 2008-06-30
NCT00761618 Intrapleural Catheter Daily Versus Three Times a Week Drainage https://ClinicalTrials.gov/show/NCT00761618 Active, not recruiting M.D. Anderson Cancer Center 2020-03-31
NCT00758316 A Prospective, Randomized Controlled Trial for a Rapid Pleurodesis Protocol for the Management of Pleural Effusions https://ClinicalTrials.gov/show/NCT00758316 Completed Singapore General Hospital 2013-06-30
NCT00637676 Tunneled Pleural Catheter in Partially Entrapped Lung https://ClinicalTrials.gov/show/NCT00637676 Completed Heidelberg University 2011-06-30
NCT00629538 Therapeutic Thoracentesis for Patients With Congestive Heart Failure and Large Pleural Effusion https://ClinicalTrials.gov/show/NCT00629538 Completed Taipei Medical University Hospital 2009-07-31
NCT00575198 Drainage Amount for Removal of Thoracostomy Tube https://ClinicalTrials.gov/show/NCT00575198 Completed University of California, Davis 2012-09-30
NCT00564733 FDG-Labeled PET Scan in Planning Chemotherapy in Treating Patients With Stage IIIB or IV Non-Small Cell Lung Cancer https://ClinicalTrials.gov/show/NCT00564733 Completed University of Washington 2011-09-30
NCT00560521 Continuous Positive Airway Pressure on Tuberculosis Pleural Effusion https://ClinicalTrials.gov/show/NCT00560521 Completed Universidade Federal do Rio de Janeiro NA
NCT00533585 BAY 43-9006 in Previously Untreated Patients With Non-Small Cell Lung Cancer (NSCLC) https://ClinicalTrials.gov/show/NCT00533585 Completed M.D. Anderson Cancer Center 2016-01-31
NCT00528645 AZD0530 in Treating Patients With Extensive Stage Small Cell Lung Cancer https://ClinicalTrials.gov/show/NCT00528645 Completed National Cancer Institute (NCI) 2008-11-30
NCT00524147 Drainage of Tuberculous Pleural Effusions https://ClinicalTrials.gov/show/NCT00524147 Completed Taipei Medical University Hospital 2005-10-31
NCT00468104 Efficacy and Safety of Activase (Ateplase) vs Placebo in Complicated Pleural Effusions (CPE)/Empyemas https://ClinicalTrials.gov/show/NCT00468104 Completed Midwest Pulmonary and Critical Care 2008-10-31
NCT00408460 Imatinib Mesylate and Paclitaxel in Treating Older Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer https://ClinicalTrials.gov/show/NCT00408460 Completed University of Washington 2010-08-31
NCT00299962 Gene Therapy for Pleural Malignancies https://ClinicalTrials.gov/show/NCT00299962 Completed University of Pennsylvania 2008-05-31
NCT00250978 Ph I:Bevacizumab + Chemotherapy in Pts w/Malig Pleural Effusion Due to Adv NSCLC https://ClinicalTrials.gov/show/NCT00250978 Completed Memorial Sloan Kettering Cancer Center 2008-04-30
NCT00247416 Effects of Carboplatin and Gemcitabine on Stage IIIB Pleural Effusion and Stage IV Lung Cancer https://ClinicalTrials.gov/show/NCT00247416 Completed University of Kentucky 2009-07-31
NCT00231465 Phase II Study of Docetaxel + ZD1839 in Elderly Patients With Non-Small Cell Lung Cancer https://ClinicalTrials.gov/show/NCT00231465 Completed H. Lee Moffitt Cancer Center and Research Institute 2012-08-31
NCT00215930 The ‘MADe IT’ Clinical Trial: Molecular Analyses Directed Individualized Therapy for Advanced Non-Small Cell Lung Cancer https://ClinicalTrials.gov/show/NCT00215930 Completed H. Lee Moffitt Cancer Center and Research Institute 2009-10-31
NCT00126581 Erlotinib Hydrochloride With or Without Carboplatin and Paclitaxel in Treating Patients With Stage III-IV Non-small Cell Lung Cancer https://ClinicalTrials.gov/show/NCT00126581 Completed National Cancer Institute (NCI) 2010-06-30
NCT00118183 Docetaxel With Either Cetuximab or Bortezomib as First-Line Therapy in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancer https://ClinicalTrials.gov/show/NCT00118183 Completed National Cancer Institute (NCI) 2007-04-30
NCT00114205 Surgery and Intrapleural Docetaxel in Treating Patients With Malignant Pleural Effusion https://ClinicalTrials.gov/show/NCT00114205 Completed National Cancer Institute (NCI) NA
NCT00099541 Non-small Cell Lung Cancer Registry https://ClinicalTrials.gov/show/NCT00099541 Completed Novartis NA
NCT00002872 Bleomycin, Doxycycline, or Talc in Treating Patients With Malignant Pleural Effusions https://ClinicalTrials.gov/show/NCT00002872 Completed Eastern Cooperative Oncology Group 2003-02-28
NCT00002622 Talc in Treating Patients With Malignant Pleural Effusion https://ClinicalTrials.gov/show/NCT00002622 Completed Alliance for Clinical Trials in Oncology 2005-03-31
NCT00004074 Interleukin-12 and Trastuzumab in Treating Patients With Cancer That Has High Levels of HER2/Neu https://ClinicalTrials.gov/show/NCT00004074 Completed National Cancer Institute (NCI) 2009-02-28
NCT00066404 Intrapleural BG00001 in Treating Patients With Malignant Pleural Mesothelioma or Malignant Pleural Effusions https://ClinicalTrials.gov/show/NCT00066404 Completed Abramson Cancer Center of the University of Pennsylvania 2006-01-31
NCT00052338 Bortezomib Plus Gemcitabine and Carboplatin in Treating Patients With Advanced or Recurrent Non-Small Cell Lung Cancer https://ClinicalTrials.gov/show/NCT00052338 Completed National Cancer Institute (NCI) 2004-05-31
NCT00042770 Standard Chest Tube Compared With a Small Catheter in Treating Malignant Pleural Effusion in Patients With Cancer https://ClinicalTrials.gov/show/NCT00042770 Completed Alliance for Clinical Trials in Oncology 2005-02-28
NCT00005906 Treatment With Octreotide in Patients With Lymphangioleiomyomatosis https://ClinicalTrials.gov/show/NCT00005906 Completed National Institutes of Health Clinical Center (CC) 2008-04-30

Observational Studiess

#If less then 500 studies

nct_id brief_title link overall_status source primary_completion_date
NCT03409055 Pleural Effusions After Cardiac Surgery https://ClinicalTrials.gov/show/NCT03409055 Completed Charite University, Berlin, Germany 2013-12-31
NCT03394872 Impact of Draining Significant Effusion on Gas Exchange and Lung Mechanics in Patient Under Mechanical Ventilation https://ClinicalTrials.gov/show/NCT03394872 Completed Dokuz Eylul University 2017-08-30
NCT03379688 PDMS Outcome After Intensive Care, Organdysfunction and Monitoring https://ClinicalTrials.gov/show/NCT03379688 Completed Charite University, Berlin, Germany 2013-12-31
NCT03319472 Using Pleural Effusions to Diagnose Cancer https://ClinicalTrials.gov/show/NCT03319472 Completed University of Patras 2017-11-21
NCT03296280 Evaluation of Implementation of a National Point-of-Care Ultrasound Training Program https://ClinicalTrials.gov/show/NCT03296280 Enrolling by invitation VA Office of Research and Development 2018-06-29
NCT03235999 The Experiences of Patients Living With Malignant Pleural Effusions https://ClinicalTrials.gov/show/NCT03235999 Recruiting Gloucestershire Hospitals NHS Foundation Trust 2019-01-31
NCT02891642 Liquid Biopsy With Immunomagnetic Beads Capture Technique for Malignant Cell Detection in Body Fluid https://ClinicalTrials.gov/show/NCT02891642 Recruiting The First Affiliated Hospital with Nanjing Medical University 2021-02-28
NCT02625675 Using Thoracic Ultrasound to Predict Pleurodesis Success in Malignant Pleural Effusions: a Pilot Study https://ClinicalTrials.gov/show/NCT02625675 Completed University of Oxford 2017-07-06
NCT02546791 Frequency and Severity of Pleural Effusion Associated With the Use of Dasatinib in Patients With Chronic Myeloid Leukemia. A Descriptive, Mexican Multicenter Study https://ClinicalTrials.gov/show/NCT02546791 Completed Bristol-Myers Squibb 2016-11-30
NCT02419196 Perioperative Change of Regional Ventilation During Spontaneous Breathing https://ClinicalTrials.gov/show/NCT02419196 Completed Wuerzburg University Hospital 2016-02-29
NCT02232841 Electrical Impedance Imaging of Patients on Mechanical Ventilation https://ClinicalTrials.gov/show/NCT02232841 Completed Colorado State University 2016-08-31
NCT02208895 iSTAT Comparison Study, IRB3785 https://ClinicalTrials.gov/show/NCT02208895 Completed University of Oklahoma 2019-08-28
NCT02104479 Diagnostic Accuracy of Pleural Effusion Aspergillosis Biomarker Testing https://ClinicalTrials.gov/show/NCT02104479 Enrolling by invitation Heidelberg University 2020-12-31
NCT02092155 Biomarker Levels During Indwelling Pleural cAtheter Sample Testing https://ClinicalTrials.gov/show/NCT02092155 Enrolling by invitation Johns Hopkins University 2020-12-31
NCT01902030 Evaluation of Performance of An Aspergillus PCR in Tissue and Pleural Effusion Samples of Immunocompromised Patients https://ClinicalTrials.gov/show/NCT01902030 Enrolling by invitation Heidelberg University 2020-12-31
NCT01616264 Reproducibility of Computed Tomography https://ClinicalTrials.gov/show/NCT01616264 Completed Universidade Federal do Rio de Janeiro 2009-10-31
NCT01560078 Efficacy Study of Thrice Weekly Directly Observed Treatment Short-Course Regimen in Tubercular Pleural Effusion https://ClinicalTrials.gov/show/NCT01560078 Completed All India Institute of Medical Sciences, New Delhi 2011-10-31
NCT01374542 Respiratory Endoscopy: Diagnostic Yield, Technical Factors and Complications https://ClinicalTrials.gov/show/NCT01374542 Recruiting Singapore General Hospital 2020-05-31
NCT04236934 Thoracentesis: Symptoms and Prediction of the Need for Therapeutic Thoracentesis https://ClinicalTrials.gov/show/NCT04236934 Recruiting Naestved Hospital 2021-08-13
NCT04235998 Value of Additional Upfront Systematic Lung Ultrasound in the Workup of Patients With Unilateral Pleural Effusion https://ClinicalTrials.gov/show/NCT04235998 Recruiting Naestved Hospital 2021-08-06
NCT03997669 The Diagnosis and Mechanism of Pleural Effusion https://ClinicalTrials.gov/show/NCT03997669 Active, not recruiting Wuhan Union Hospital, China 2020-02-01
NCT03846934 Positive and Quantitative Diagnosis of Pleural Effusions by Thoracic Ultrasonography in Patients With Acute Respiratory Failure in the Emergency Department https://ClinicalTrials.gov/show/NCT03846934 Recruiting University Hospital, Limoges 2021-04-14
NCT03737695 Clinical Information and Biospecimen Collection From Patients With Recurrent or Stage IV Breast Cancer https://ClinicalTrials.gov/show/NCT03737695 Recruiting Mayo Clinic 2020-11-05
NCT03661801 Novel Pleural Fluid, Biopsy and Serum Biomarkers for the Investigation of Pleural Effusions https://ClinicalTrials.gov/show/NCT03661801 Recruiting University of Oxford 2021-09-25
NCT03656822 Data Visualization of Kidney and Prostate Tumors Using Routine Pre-Operative Imaging, 3D Printed, and 3D Virtual Reality Models https://ClinicalTrials.gov/show/NCT03656822 Completed NYU Langone Health 2019-12-31
NCT03535883 The Safety of Thoracentesis, Tunneled Pleural Catheter, and Chest Tubes in Patients Taking Novel Oral Anti-Coagulants https://ClinicalTrials.gov/show/NCT03535883 Recruiting Yale University 2020-09-30
NCT03482570 Activity Behaviours in Patients With Malignant Pleural Effusion https://ClinicalTrials.gov/show/NCT03482570 Recruiting The University of Hong Kong 2019-12-31
NCT01256801 Gene Expression Profiling of Breast Cancer Cells Predict the Response of Malignant Pleural Effusion https://ClinicalTrials.gov/show/NCT01256801 Completed Beijing Cancer Hospital 2013-01-31
NCT01178580 Procoagulant Activity in Patients With Community Acquired Pneumonia, Pleural Effusion and Empyema https://ClinicalTrials.gov/show/NCT01178580 Completed Meir Medical Center 2011-08-31
NCT01117740 Pleural Catheters Versus Thoracoscopic Pleurodesis https://ClinicalTrials.gov/show/NCT01117740 Completed M.D. Anderson Cancer Center 2016-04-30
NCT01104285 Chest Tube Drainage of Transudative Pleural Effusions Hastens Liberation From Mechanical Ventilation https://ClinicalTrials.gov/show/NCT01104285 Completed Maimonides Medical Center 2010-04-30
NCT00915161 Sustained Effects of Thoracocentesis in Mechanically Ventilated Patients https://ClinicalTrials.gov/show/NCT00915161 Completed Oxford University Hospitals NHS Trust 2008-08-31
NCT03597828 Respiratory Function of Dexmedetomidine in Patients Undergoing Pleuroscopy https://ClinicalTrials.gov/show/NCT03597828 Completed Attikon Hospital 2020-06-30
NCT00665015 Pleural Effusion Following Cardiac Surgery: Prevalence, Risk Factors and Clinical Features https://ClinicalTrials.gov/show/NCT00665015 Completed Laval University 2005-12-31
NCT00646490 Pleural Fluid and Serum Procalcitonin in Patients With Parapneumonic Pleural Effusion https://ClinicalTrials.gov/show/NCT00646490 Completed Chang Gung Memorial Hospital 2009-07-31
NCT00473291 Vibration Response Imaging (VRI) in Management and Evaluation in Patients With Pleural Effusion https://ClinicalTrials.gov/show/NCT00473291 Completed Deep Breeze NA
NCT00258518 Respiratory Mechanics and Pleural Effusion https://ClinicalTrials.gov/show/NCT00258518 Completed Policlinico Hospital 2011-06-30
NCT00188474 A Quality of Life Study re Management of Malignant Pleural Effusions https://ClinicalTrials.gov/show/NCT00188474 Completed University Health Network, Toronto 2013-11-30

Registries

#If less then 500 registries

nct_id brief_title link overall_status source primary_completion_date
NCT03276715 Prognostic Factors on Malignant Pleural Effusion https://ClinicalTrials.gov/show/NCT03276715 Completed The University of Hong Kong 2018-10-01
NCT03210298 International Registry of Patients Treated With Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) https://ClinicalTrials.gov/show/NCT03210298 Recruiting University of Magdeburg 2022-09-30
NCT03189654 Noninvasive Ventilation Therapy for the Treatment of Pleural Effusion in Patients With Heart Failure https://ClinicalTrials.gov/show/NCT03189654 Recruiting Heart and Diabetes Center North-Rhine Westfalia 2019-12-31
NCT03064659 Driving Pressure And EFL in Adult Cardiac Surgery https://ClinicalTrials.gov/show/NCT03064659 Completed Ospedale San Raffaele 2017-01-31